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Dec 8, 2020 · All data and procedures are provided in the article and SI Appendix. Significance Protein phase separation is a progressive process of high-ordered assembly in vitro, which can experience dynamic liquid–liquid phase separation (LLPS) followed by maturation into pathological solid fibrils. 5CQ2, 5DF6. PubMed Abstract: TXNIP (thioredoxin-interacting protein) negatively regulates the antioxidative activity of thioredoxin and participates in pleiotropic cellular processes. Its deregulation is linked to various human diseases, including diabetes, acute myeloid leukaemia and cardiovascular diseases. The E3 ubiquitin ligase Itch (Itchy ...…

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